Organocatalytic asymmetric “anti-Michael” reaction of β-ketoesters
نویسندگان
چکیده
منابع مشابه
Organocatalytic asymmetric "anti-Michael" reaction of beta-ketoesters.
The first organocatalytic "anti-Michael" reaction of cyclic-beta-ketoesters to unsaturated double bonds is described in a highly asymmetric version leading to the synthesis of alpha,alpha'-disubstituted branched double bonds as optically active Baylis-Hillman-like adducts.
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The visible-light-driven, phase-transfer-catalyzed, enantioselective perfluoroalkylation and trifluoromethylation of cyclic β-ketoesters is described. The photo-organocatalytic process, which occurs at ambient temperature and under visible light illumination, is triggered by the photochemical activity of in situ-generated electron donor-acceptor complexes, arising from the association of chiral...
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A Michael-type reaction of β,γ-unsaturated α-keto ester and α-nitro ketone was established. With a thiourea catalyst derived from cinchona alkaloid, the reactions afford products in 47-94% yields with 68-96% ee.
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2007
ISSN: 1359-7345,1364-548X
DOI: 10.1039/b710393j